Updated Resources on Folate, Folic Acid, Neural Tube Defects and MTHFR Gene Variants in TTC and Pregnancy

Shannon M. Clark, MD
November 23, 2022
Updated Resources on Folate, Folic Acid, Neural Tube Defects and MTHFR Gene Variants in TTC and Pregnancy

Please click on this link to a Google document to get updated info on folate, folic acid, neural tube defects and MTHFR gene variants in TTC and pregnancy. This document contains numerous resources and links to scientific articles for your review.

The following topics are addressed:

  • What is folic acid (FA)?
  • Are folate and folic acid the same thing?
  • How much folic acid do I need?
  • What is the recommended daily amount of folic acid to prevent neural tube defects?
  • How do I read the nutrition label to make sure I am getting enough folic acid?
  • How can I get folic acid?
  • What can happen with folate deficiency in pregnancy?
  • Who needs a higher dose of folic acid?
  • What do I need to do if I have a baby with a neural tube defect?
  • Can my baby still have a neural tube defect even if I take folic acid?
  • What is difference between supplementation and fortification?
  • Has supplementation and fortification helped reduce neural tube defects?
  • Can I take another form of folate to prevent neural tube defects?
  • Why aren’t other forms of folate used in food fortification?
  • Who recommends folic acid for neural tube defect prevention?
  • What is blood folate concentration?
  • Is folic acidsafe to take in pregnancy?
  • What is unmetabolized folic acid?
  • What is the tolerable upper intake level (UL) for folic acid?
  • Does folic acid mask vitamin b12 deficiency?
  • What is the MTHFR gene variant?
  • Can people with MTHFR gene variants take folic acid?
  • MTHFR gene variants, folic acid and tongue tie
  • Folic acid and epigenetic alterations
  • Folic acid and neurocognitive development
  • Does FA supplementation increase rate of twinning?
  • Dangers of the designer PNV and online misinformation

You can also go to my Instagram for more info under my "folic acid 1. 2. and 3" highlights, as well as my "MTHFR" highlight.

Shannon M. Clark, MD

Shannon M. Clark, MD

Shannon M. Clark, MD, MMS is a double board certified ObGyn and Maternal-Fetal Medicine Specialist, and founder of Babies After 35. In her roles as a clinician, educator and researcher at UTMB-Galveston, she focuses on the care of people with maternal and/or fetal complications of pregnancy. Dr. Clark has taken a special interest in pregnancy after the age of 35, which according to age alone, is considered a high-risk pregnancy.

Follow Shannon on TikTok @tiktokbabydoc, Facebook @babiesafter35, and Instagram @babiesafter35.

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